OR51E1 explained
Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Ligands
The receptor is associated with some compounds with a "cheese" or "sour" scent note.Examples of compounds that activate OR51E1 include:
The following are in decreasing order of activity:[5]
See also
Further reading
- Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M . The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase . The Prostate . 66 . 8 . 847–57 . June 2006 . 16491480 . 10.1002/pros.20389 . 25548828 .
- Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M . PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer . International Journal of Cancer . 118 . 6 . 1471–80 . March 2006 . 16206286 . 10.1002/ijc.21527 . 23711956 .
- Weigle B, Fuessel S, Ebner R, Temme A, Schmitz M, Schwind S, Kiessling A, Rieger MA, Meye A, Bachmann M, Wirth MP, Rieber EP . 6 . D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate . Biochemical and Biophysical Research Communications . 322 . 1 . 239–49 . September 2004 . 15313197 . 10.1016/j.bbrc.2004.07.106 .
- Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proceedings of the National Academy of Sciences of the United States of America . 101 . 8 . 2584–9 . February 2004 . 14983052 . 356993 . 10.1073/pnas.0307882100 . 2004PNAS..101.2584M . free .
- Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF . Novel human G-protein-coupled receptors . Biochemical and Biophysical Research Communications . 305 . 1 . 67–71 . May 2003 . 12732197 . 10.1016/S0006-291X(03)00709-5 .
- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . 6 . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence . Nature . 377 . 6547 Suppl . 3–174 . September 1995 . 7566098 .
Notes and References
- Web site: Entrez Gene: OR51E1 olfactory receptor, family 51, subfamily E, member 1.
- Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD . Odor coding by a Mammalian receptor repertoire . Science Signaling . 2 . 60 . ra9 . March 2009 . 19261596 . 2774247 . 10.1126/scisignal.2000016 .
- Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, Moberly AH, Adipietro KA, Liu WL, Zhuang H, Zhan S, Lee SS, Lin A, Matsunami H . 6 . The missense of smell: functional variability in the human odorant receptor repertoire . Nature Neuroscience . 17 . 1 . 114–20 . January 2014 . 24316890 . 10.1038/nn.3598 . 3990440 .
- Fujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R . Deorphanization of Dresden G protein-coupled receptor for an odorant receptor . Journal of Receptor and Signal Transduction Research . 27 . 4 . 323–34 . 2007 . 17885925 . 10.1080/10799890701534180 . 42999502 .
- Adipietro KA, Mainland JD, Matsunami H . Functional evolution of mammalian odorant receptors . PLOS Genetics . 8 . 7 . e1002821 . 2012 . 22807691 . 3395614 . 10.1371/journal.pgen.1002821 . free .
