OR51B2 explained

Olfactory receptor 51B2 is a protein that in humans is encoded by the OR51B2 gene.^[1]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

As of 2015, OR51B2 was an orphan receptor, meaning that no odorants have been identified which bind to it.^[2]

See also

• Olfactory receptor

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH . Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes . Proceedings of the National Academy of Sciences of the United States of America . 96 . 9 . 5129–34 . April 1999 . 10220430 . 21828 . 10.1073/pnas.96.9.5129 . 1999PNAS...96.5129B . free .
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R . Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters . Proceedings of the National Academy of Sciences of the United States of America . 97 . 26 . 14560–5 . December 2000 . 11121057 . 18958 . 10.1073/pnas.97.26.14560 . 2000PNAS...9714560B . free .
• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R . DEFOG: a practical scheme for deciphering families of genes . Genomics . 80 . 3 . 295–302 . September 2002 . 12213199 . 10.1006/geno.2002.6830 .

Notes and References

1. Web site: Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2.
2. de March . Claire A. . Ryu . SangEun . Sicard . Gilles . Moon . Cheil . Golebiowski . Jérôme . vanc . Structure–odour relationships reviewed in the postgenomic era . Flavour and Fragrance Journal . September 2015 . 30 . 5 . 342–361 . 10.1002/ffj.3249 .