OR3A4 explained
Olfactory receptor 3A4 is a protein that in humans is encoded by the OR3A4 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
See also
Further reading
- Ben-Arie N, Lancet D, Taylor C, etal . Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire . Hum. Mol. Genet. . 3 . 2 . 229–35 . 1994 . 8004088 . 10.1093/hmg/3.2.229 .
- Glusman G, Clifton S, Roe B, Lancet D . Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity . Genomics . 37 . 2 . 147–60 . 1997 . 8921386 . 10.1006/geno.1996.0536 .
- Glusman G, Sosinsky A, Ben-Asher E, etal . Sequence, structure, and evolution of a complete human olfactory receptor gene cluster . Genomics . 63 . 2 . 227–45 . 2000 . 10673334 . 10.1006/geno.1999.6030 . 23416814 .
- Fuchs T, Malecova B, Linhart C, etal . DEFOG: a practical scheme for deciphering families of genes . Genomics . 80 . 3 . 295–302 . 2003 . 12213199 . 10.1006/geno.2002.6830 .
- Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .
Notes and References
- Web site: Entrez Gene: OR3A4 olfactory receptor, family 3, subfamily A, member 4.
