OR2W1 explained

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[2]

Ligands

Out of 10 human ORs studied, OR2W1 was the most broadly tuned, meaning it responds to the greatest variety of different odorant molecules.^[3]

Ligands, in decreasing order of sensitivity:^[3]

• 2-Heptanone
• 1-Octanal
• (-)-Citronellol
• Hexanal
• 3-Octanone
• Hexyl acetate
• 1-Hexanol
• Octanoic acid
• 1-Heptanol
• Allyl phenylacetate
• Benzyl acetate^[4]
• 3,4-Hexanedione

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R . 6 . DEFOG: a practical scheme for deciphering families of genes . Genomics . 80 . 3 . 295–302 . September 2002 . 12213199 . 10.1006/geno.2002.6830 . 10.1.1.135.3652 .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proceedings of the National Academy of Sciences of the United States of America . 101 . 8 . 2584–9 . February 2004 . 14983052 . 356993 . 10.1073/pnas.0307882100 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1.
2. Web site: Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1.
3. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD . Odor coding by a Mammalian receptor repertoire . Science Signaling . 2 . 60 . ra9 . March 2009 . 19261596 . 2774247 . 10.1126/scisignal.2000016 .
4. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O . 6 . Identification of odorant-receptor interactions by global mapping of the human odorome . PLOS ONE . 9 . 4 . e93037 . 2014 . 24695519 . 3973694 . 10.1371/journal.pone.0093037 . 2014PLoSO...993037A . free .