OR2T4 explained

Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[2]

Ligands

OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:

• Farnesol
• Lilial
• Undecanal^[3]

See also

• Olfactory receptor

Further reading

• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4.
2. Web site: Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4.
3. Rapid Deorphanization of Human Olfactory Receptors in Yeast . Biochemistry . Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P . 2019 . 58 . 16 . 2160–2166 . 10.1021/acs.biochem.8b01208. 30977365 . 6482435 .