OR2M3 explained

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

OR2M3 has a copper binding pocket.^[2]

Ligands

• 3-Mercapto-2-methylpentan-1-ol ^[3]

This chemical is associated with characteristic smell of raw onions.

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R . 6 . DEFOG: a practical scheme for deciphering families of genes . Genomics . 80 . 3 . 295–302 . September 2002 . 12213199 . 10.1006/geno.2002.6830 .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proceedings of the National Academy of Sciences of the United States of America . 101 . 8 . 2584–9 . February 2004 . 14983052 . 356993 . 10.1073/pnas.0307882100 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR2M3 olfactory receptor, family 2, subfamily M, member 3.
2. Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D . Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3 . Cellular and Molecular Life Sciences . 77. 11. August 2019 . 31435697 . 10.1007/s00018-019-03279-y . free . 7256108 . 2157–2179 .
3. Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D . OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol . Chemical Senses . 42 . 3 . 195–210 . March 2017 . 27916748 . 10.1093/chemse/bjw118 . free .