OR2AG1 explained

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[2]

Ligands

Amyl butyrate is a reported ligand for this receptor. ^[3]

See also

• Olfactory receptor

Further reading

• Lane RP, Cutforth T, Young J, etal . Genomic analysis of orthologous mouse and human olfactory receptor loci. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 13 . 7390–5 . 2001 . 11416212 . 10.1073/pnas.131215398 . 34679 . 2001PNAS...98.7390L . free .
• Fuchs T, Malecova B, Linhart C, etal . DEFOG: a practical scheme for deciphering families of genes. . Genomics . 80 . 3 . 295–302 . 2003 . 12213199 . 10.1006/geno.2002.6830 . 10.1.1.135.3652 .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .
• Neuhaus EM, Mashukova A, Zhang W, etal . A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. . Chem. Senses . 31 . 5 . 445–52 . 2006 . 16565291 . 10.1093/chemse/bjj049 . free .
• Mashukova A, Spehr M, Hatt H, Neuhaus EM . Beta-arrestin2-mediated internalization of mammalian odorant receptors. . J. Neurosci. . 26 . 39 . 9902–12 . 2006 . 17005854 . 6674477 . 10.1523/JNEUROSCI.2897-06.2006 .

Notes and References

1. Web site: Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1.
2. Web site: Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1.
3. Shepard BD, Pluznick JL . How does your kidney smell? Emerging roles for olfactory receptors in renal function . Pediatric Nephrology (Berlin, Germany) . 31 . 5 . 715–23 . May 2016 . 26264790 . 4752438 . 10.1007/s00467-015-3181-8 .