OR1J2 explained

Olfactory receptor 1J2 is a protein that in humans is encoded by the OR1J2 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Parmentier M, Libert F, Schurmans S, etal . Expression of members of the putative olfactory receptor gene family in mammalian germ cells. . Nature . 355 . 6359 . 453–5 . 1992 . 1370859 . 10.1038/355453a0 . 1992Natur.355..453P . 43926 .
• Rouquier S, Blancher A, Giorgi D . The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 6 . 2870–4 . 2000 . 10706615 . 10.1073/pnas.040580197 . 16022 . 2000PNAS...97.2870R . free .
• Fuchs T, Malecova B, Linhart C, etal . DEFOG: a practical scheme for deciphering families of genes. . Genomics . 80 . 3 . 295–302 . 2003 . 12213199 . 10.1006/geno.2002.6830 .
• Gilad Y, Bustamante CD, Lancet D, Pääbo S . Natural selection on the olfactory receptor gene family in humans and chimpanzees. . Am. J. Hum. Genet. . 73 . 3 . 489–501 . 2003 . 12908129 . 10.1086/378132 . 1180675 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR1J2 olfactory receptor, family 1, subfamily J, member 2.