OR1G1 explained

Olfactory receptor 1G1 is a protein that in humans is encoded by the OR1G1 gene.[1] [2] [3]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

The OR1G1 receptor is associated with sensory sensations including "waxy", "fatty", and "rose",[4] and also "fruity" and "sweet".[5]

Compared to other olfactory receptors such as OR52D1, OR1G1 is broadly tuned to respond to odorants in different chemical classes, but it is sensitive to chain length, responding most strongly to chains of 9-10 carbons.[6]

Examples of agonists include:

Example antagonists include:

The pattern of 6-carbon antagonists compared to ~9-carbon agonists is likely explained by OR1G1 having a deep pocket at its binding site, such that the 6-carbon molecules block the opening, but do not reach the bottom of the deep pocket as required to activate the signal transduction chain.[6]

See also

Further reading

Notes and References

  1. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H . 6 . Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire . Human Molecular Genetics . 3 . 2 . 229–35 . February 1994 . 8004088 . 10.1093/hmg/3.2.229 .
  2. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D . Distribution of olfactory receptor genes in the human genome . Nature Genetics . 18 . 3 . 243–50 . March 1998 . 9500546 . 10.1038/ng0398-243 . 31129045 .
  3. Web site: Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1.
  4. Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A . 6 . Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor . Chemical Senses . 33 . 7 . 639–53 . September 2008 . 18603653 . 10.1093/chemse/bjn032 . free . 10.1.1.563.7800 .
  5. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O . 6 . Identification of odorant-receptor interactions by global mapping of the human odorome . PLOS ONE . 9 . 4 . e93037 . 2014 . 24695519 . 3973694 . 10.1371/journal.pone.0093037 . 2014PLoSO...993037A . free .
  6. Sanz G, Schlegel C, Pernollet JC, Briand L . Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism . Chemical Senses . 30 . 1 . 69–80 . January 2005 . 15647465 . 10.1093/chemse/bji002 . free .
  7. Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, Cerutti M, Etiévant P, Ronin C . 6 . Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system . Chemical Senses . 30 . 3 . 195–207 . March 2005 . 15741602 . 10.1093/chemse/bji015 . free .