OR1A2 explained

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.^{[1] [2]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1.^[3] Examples of known ligands, most of which have citrus or fruity smells:^{[3] [4]}

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal^[3])
• Hydroxycitronellal
• Citral
• (S)-(−)-Citronellol (in contrast to OR1A1 only this enantiomer is effective; weaker than citronellal^[3])

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, etal . DEFOG: a practical scheme for deciphering families of genes . Genomics . 80 . 3 . 295–302 . 2003 . 12213199 . 10.1006/geno.2002.6830 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D . Sequence, structure, and evolution of a complete human olfactory receptor gene cluster . Genomics . 63 . 2 . 227–45 . Apr 2000 . 10673334 . 10.1006/geno.1999.6030 . 23416814 .
2. Web site: Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2.
3. Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D . Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2 . Journal of Structural Biology . 159 . 3 . 400–12 . September 2007 . 17601748 . 10.1016/j.jsb.2007.04.013 .
4. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O . 6 . Identification of odorant-receptor interactions by global mapping of the human odorome . PLOS ONE . 9 . 4 . e93037 . 2014 . 24695519 . 3973694 . 10.1371/journal.pone.0093037 . 2014PLoSO...993037A . free .