OR10J5 explained

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

OR10J5 is a relatively narrowly-tuned receptor, meaning it responds only to a relatively small set of related odorants.^[2]

Ligands include Lyral,^[2] an aldehyde with a soft floral scent.

Further reading

• Gilad Y, Bustamante CD, Lancet D, Pääbo S . Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees . Am. J. Hum. Genet. . 73 . 3 . 489–501 . 2003 . 12908129 . 10.1086/378132 . 1180675 .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2584–9 . 2004 . 14983052 . 10.1073/pnas.0307882100 . 356993 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5.
2. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD . Odor coding by a Mammalian receptor repertoire . Science Signaling . 2 . 60 . ra9 . March 2009 . 19261596 . 2774247 . 10.1126/scisignal.2000016 .