CUT domain explained

Symbol:	CUT
CUT
Pfam:	PF02376
Interpro:	IPR003350
Scop:	1wh6

In molecular biology, the CUT domain (also known as ONECUT) is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, which is often found downstream of the CUT domain. Proteins display two modes of DNA binding, which hinge on the homeodomain and on the linker that separates it from the CUT domain, and two modes of transcriptional stimulation, which hinge on the homeodomain.^{[1] [2]}

Notes and References

1. Lannoy VJ, Burglin TR, Rousseau GG, Lemaigre FP . Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins . J. Biol. Chem. . 273 . 22 . 13552–62 . May 1998 . 9593691 . 10.1074/jbc.273.22.13552. free .
2. Yamasaki . K. . Akiba . T. . Yamasaki . T. . Harata . K. . Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1 . 10.1093/nar/gkm504 . Nucleic Acids Research . 35 . 15 . 5073–5084 . 2007 . 17652321 . 1976457 .