Solute carrier organic anion transporter family member 4c1 explained

Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.^{[1] [2]}

Function

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).

Notes and References

1. Mikkaichi T, Suzuki T, Onogawa T, etal . Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc. Natl. Acad. Sci. U.S.A.. 101. 10. 3569–74. March 2004. 14993604. 373503. 10.1073/pnas.0304987101. 2004PNAS..101.3569M. free.
2. Web site: Entrez Gene: Solute carrier organic anion transporter family member 4C1. 2016-03-11.