OAS2 explained
2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[1] [2]
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
Further reading
- Justesen J, Hartmann R, Kjeldgaard NO . Gene structure and function of the 2'-5'-oligoadenylate synthetase family . Cell. Mol. Life Sci. . 57 . 11 . 1593–1612 . 2000 . 11092454 . 10.1007/PL00000644 . 19154357 . free . 11146851 .
- Marié I, Hovanessian AG . The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains . J. Biol. Chem. . 267 . 14 . 9933–9 . 1992 . 10.1016/S0021-9258(19)50182-X . 1577824 . free .
- Silverman RH, Sengupta DN . Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes . J. Exp. Pathol. . 5 . 2 . 69–77 . 1991 . 1708818 .
- Marié I . Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon . J. Biol. Chem. . 265 . 30 . 18601–7 . 1990 . 2211721 . vanc. Svab J . Robert N . 3 . Galabru . J . Hovanessian . AG . 10.1016/S0021-9258(17)44794-6 . free .
- Hovanessian AG . Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies . EMBO J. . 6 . 5 . 1273–80 . 1987 . 2440675 . 10.1002/j.1460-2075.1987.tb02364.x. 553929 . vanc. Laurent AG . Chebath J . 3 . Galabru . J . Robert . N . Svab . J .
- Marié I, Galabru J, Svab J, Hovanessian AG . Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase . Biochem. Biophys. Res. Commun. . 160 . 2 . 580–587 . 1989 . 2470369 . 10.1016/0006-291X(89)92472-8 .
- Hovanessian AG . Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells . J. Biol. Chem. . 263 . 10 . 4945–9 . 1988 . 3350819 . vanc. Svab J . Marié I . 3 . Robert . N . Chamaret . S . Laurent . AG . 10.1016/S0021-9258(18)68878-7 . free .
- Solinas A . Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C . Liver . 13 . 5 . 253–8 . 1994 . 8259037 . 10.1111/j.1600-0676.1993.tb00640.x. vanc. Cossu P . Poddighe P . 3 . Tocco . A . Deplano . A . Garrucciu . G . Diana . MS .
- Besse S . Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells . Exp. Cell Res. . 239 . 2 . 379–392 . 1998 . 9521856 . 10.1006/excr.1997.3908 . vanc. Rebouillat D . Marie I . 3 . Puvion-Dutilleul . F . Hovanessian . AG .
- Sarkar SN . The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases . J. Biol. Chem. . 274 . 36 . 25535–25542 . 1999 . 10464285 . 10.1074/jbc.274.36.25535 . vanc. Ghosh A . Wang HW . 3 . Sung . SS . Sen . GC . free.
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Scherer SE . The finished DNA sequence of human chromosome 12 . Nature . 440 . 7082 . 346–351 . 2006 . 16541075 . 10.1038/nature04569 . vanc. Muzny DM . Buhay CJ . 3 . Chen . Rui . Cree . Andrew . Ding . Yan . Dugan-Rocha . Shannon . Gill . Rachel . Gunaratne . Preethi . 2006Natur.440..346S . free .
Notes and References
- Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG . The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms . Genomics . 52 . 3 . 267–277 . Dec 1998 . 9790745 . 10.1006/geno.1998.5443 .
- Web site: Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa.