O-sialoglycoprotein endopeptidase explained
| O-sialoglycoprotein endopeptidase |
| Ec Number: | 3.4.24.57 |
| Cas Number: | 129430-53-1 |
O-sialoglycoprotein endopeptidase (glycoprotease, glycophorin A proteinase, glycoproteinase, sialoglycoprotease, sialoglycoproteinase, "OSGE") is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
This enzyme is secreted by the bacterium Pasteurella haemolytica.
Notes and References
- Abdullah KM, Lo RY, Mellors A . Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene . Journal of Bacteriology . 173 . 18 . 5597–603 . September 1991 . 1885539 . 208286 . 10.1128/jb.173.18.5597-5603.1991 .
- Abdullah KM, Udoh EA, Shewen PE, Mellors A . A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins . Infection and Immunity . 60 . 1 . 56–62 . January 1992 . 1729196 . 257502 .
- Sutherland DR, Abdullah KM, Cyopick P, Mellors A . Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica . Journal of Immunology . 148 . 5 . 1458–64 . March 1992 . 1371528 .
