O-4210 Explained

O-4210 is a drug developed by Organix Inc which acts as a selective dopamine reuptake inhibitor, with good selectivity over the serotonin transporter but its activity at the noradrenaline transporter is not known. It is a thiatropane derivative, related in chemical structure to phenyltropane derivatives such as RTI-126 and RTI-171, but with the amine nitrogen replaced by sulfur, demonstrating that this nitrogen only plays a minor contribution to receptor binding, in a similar manner to the related oxatropane tropoxane.^{[1] [2]}

See also

• List of phenyltropanes

Notes and References

1. Pham-Huu DP, Deschamps JR, Liu S, Madras BK, Meltzer PC . Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters . Bioorganic & Medicinal Chemistry . 15 . 2 . 1067–82 . January 2007 . 17070057 . 1829488 . 10.1016/j.bmc.2006.10.016 .
2. Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC . The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes . Bioorganic & Medicinal Chemistry Letters . 21 . 1 . 48–51 . January 2011 . 21146984 . 3015105 . 10.1016/j.bmcl.2010.11.076 .