O-2172 Explained

O-2172 is a drug developed by Organix Inc, which acts as a stimulant and potent dopamine reuptake inhibitor. It is an analogue of methylphenidate where the phenyl ring has had a 3,4-dichloro substitution added, and the piperidine ring has been replaced by cyclopentane. It is around 1/3 the potency of methylphenidate, demonstrating that even with the important binding group of the nitrogen lone pair removed entirely, selective DAT binding and reuptake inhibition is still possible.^{[1] [2]}

See also

• Tropoxane
• O-4210
• 3,4-Dichloromethylphenidate

Notes and References

1. Meltzer PC, Wang P, Blundell P, Madras BK . Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate . Journal of Medicinal Chemistry . 46 . 8 . 1538–45 . April 2003 . 12672255 . 10.1021/jm0205292 .
2. Runyon SP, Carroll FI . Dopamine transporter ligands: recent developments and therapeutic potential . Current Topics in Medicinal Chemistry . 6 . 17 . 1825–43 . 17017960 . 10.2174/156802606778249775 . 2006 .