O-1871 Explained

O-1871 is a potent cannabinoid agonist which was invented by Billy R Martin and Raj K Razdan at Organix Inc in 2002. It has a CB₁ receptor affinity of 2.0 nM and a CB₂ receptor affinity of 0.3 nM.^[1] Structurally, O-1871 is a cyclohexylphenol derivative related to CP 47,497,^[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivative O-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,^[3] which are not cyclohexylphenol derivatives.

See also

• CP 55,940
• Cannabidiol
• Cannabicyclohexanol
• Cannabinor

Notes and References

1. WO . 03091189 . application . Cannabinoids . 6 November 2003 . 20 June 2002 . 25 June 2002 . Martin BR, Razdan RK . University of Virginia .
2. Debruyne D, Le Boisselier R . Emerging drugs of abuse: current perspectives on synthetic cannabinoids . Substance Abuse and Rehabilitation . 2015 . 6 . 113–29 . 26543389 . 10.2147/SAR.S73586 . 4622447 . free .
3. US . 2004087590 . application . Novel biphenyl and biphenyl-like cannabinoids. 6 May 2004 . Lai XZ, Lu D, Makriyannis A. University of Connecticut .