O-1057 Explained

O-1057 is an analgesic cannabinoid derivative created by Organix Inc., Newburyport, Massachusetts, for use in scientific research. Unlike most cannabinoids discovered to date, it is water-soluble, which gives it considerable advantages over many related cannabinoids. It has moderate affinity for both CB₁ and CB₂ receptors, with K_i values of 8.36 nM at CB₁ and 7.95 nM at CB₂^[1]

See also

• AM-2232
• O-774
• O-1812
• O-2694
• SP-111

Notes and References

1. Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR . O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties . British Journal of Pharmacology . 129 . 8 . 1577–84 . April 2000 . 10780961 . 1572002 . 10.1038/sj.bjp.0703245 .