| Official Name: | Nyssa, Missouri |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Missouri#USA |
| Pushpin Label: | Nyssa |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Butler |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 440 |
| Coordinates: | 36.6398°N -90.2426°W |
| Area Code: | 573 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 740009 |
Nyssa is an unincorporated community in southeast Butler County, in the U.S. state of Missouri.
The community is on Missouri Route 51 2.5 miles south of Broseley and three miles north of Qulin. Poplar Bluff is eleven miles to the northwest.[1]
The community was a timber station on the old Chicago, Burlington and Quincy Railroad. Nyssa is the generic botanical name for the locally abundant tupelo gum. William N. Barron gave the town its name.[2]