NR4A explained

NR4A (nuclear receptor subfamily 4A) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance. In 2006, it was shown that members of the NR4A family were implicated in the control of skeletal muscle metabolism.^{[1] [2]}

Three members have been identified in humans:^{[3] [4]}

• Nuclear receptor 4A1,
• Nuclear receptor 4A2, and
• Nuclear receptor 4A3 .

Notes and References

1. Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE . The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle . Endocrinology . 147 . 11 . 5217–27 . 2006 . 16901967 . 10.1210/en.2006-0447 . free .
2. Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE . The Orphan Nuclear Receptor, NOR-1, a Target of -Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle . Endocrinology . 149 . 6 . 2853–65 . 2008 . 18325999 . 10.1210/en.2007-1202 . free .
3. Maxwell MA, Muscat GE . The NR4A subgroup: immediate early response genes with pleiotropic physiological roles . Nucl Recept Signal . 4 . e002 . 2006 . 16604165 . 10.1621/nrs.04002. 1402209 .
4. Maheux J, Ethier I, Rouillard C, Lévesque D . Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action . J. Pharmacol. Exp. Ther. . 313 . 1 . 460–73 . 2005 . 15615863 . 10.1124/jpet.104.080184 . 20.500.11794/17025 . 1436507 . free .