This is a list of the German Media Control Top100 Singles Chart number-ones of 1959.
| Song | Artist | |
| 3 January | "La Paloma" | Billy Vaughn |
| 10 January | ||
| 17 January | ||
| 24 January | ||
| 31 January | "Tom Dooley" | Nilsen Brothers |
| 7 February | ||
| 14 February | ||
| 21 February | ||
| 28 February | ||
| 7 March | ||
| 14 March | ||
| 21 March | Kingston Trio | |
| 28 March | ||
| 4 April | ||
| 11 April | ||
| 18 April | ||
| 25 April | "Die Gitarre und das Meer" | Freddy Quinn |
| 2 May | ||
| 9 May | ||
| 16 May | ||
| 23 May | ||
| 30 May | ||
| 6 June | ||
| 13 June | ||
| 20 June | ||
| 27 June | ||
| 4 July | ||
| 11 July | ||
| 18 July | ||
| 25 July | ||
| 1 August | "Am Tag, als der Regen kam" | Dalida |
| 8 August | ||
| 15 August | ||
| 22 August | ||
| 29 August | ||
| 5 September | ||
| 12 September | ||
| 19 September | ||
| 26 September | ||
| 3 October | ||
| 10 October | "Souvenirs" | Bill Ramsey |
| 17 October | ||
| 24 October | ||
| 31 October | ||
| 7 November | ||
| 14 November | ||
| 21 November | "Unter fremden Sternen" | Freddy Quinn |
| 28 November | ||
| 5 December | ||
| 12 December | ||
| 19 December | ||
| 26 December |