Nucleoporin 85 Explained

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.^{[1] [2]}

Function

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.^[2]

Further reading

• Kapeller R, Toker A, Cantley LC, Carpenter CL . Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin . The Journal of Biological Chemistry . 270 . 43 . 25985–91 . Oct 1995 . 7592789 . 10.1074/jbc.270.43.25985 . free .
• Tynan SH, Purohit A, Doxsey SJ, Vallee RB . Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin . The Journal of Biological Chemistry . 275 . 42 . 32763–8 . Oct 2000 . 10893222 . 10.1074/jbc.M001536200 . free .
• Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ . Proteomic analysis of the mammalian nuclear pore complex . The Journal of Cell Biology . 158 . 5 . 915–27 . Sep 2002 . 12196509 . 2173148 . 10.1083/jcb.200206106 .
• Mulari MT, Patrikainen L, Kaisto T, Metsikkö K, Salo JJ, Väänänen HK . The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species . Experimental Cell Research . 285 . 2 . 221–35 . May 2003 . 12706117 . 10.1016/S0014-4827(03)00033-8 .
• Chang F, Re F, Sebastian S, Sazer S, Luban J . HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes . Molecular Biology of the Cell . 15 . 4 . 1793–801 . Apr 2004 . 14767062 . 379276 . 10.1091/mbc.E03-09-0691 .
• Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V . The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis . Molecular Biology of the Cell . 15 . 7 . 3333–44 . Jul 2004 . 15146057 . 452587 . 10.1091/mbc.E03-12-0878 .
• Terashima Y, Onai N, Murai M, Enomoto M, Poonpiriya V, Hamada T, Motomura K, Suwa M, Ezaki T, Haga T, Kanegasaki S, Matsushima K . Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis . Nature Immunology . 6 . 8 . 827–35 . Aug 2005 . 15995708 . 10.1038/ni1222 . 23496938 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M . A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart . Journal of Cardiac Failure . 13 . 2 . 114–9 . Mar 2007 . 17395051 . 10.1016/j.cardfail.2006.11.003 .

Notes and References

1. Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M . Pericentrin, a highly conserved centrosome protein involved in microtubule organization . Cell . 76 . 4 . 639–50 . Feb 1994 . 8124707 . 10.1016/0092-8674(94)90504-5 . 20503793 .
2. Web site: Entrez Gene: NUP85 nucleoporin 85kDa.