Nucleoporin 35 Explained

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.

Background

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.^[1]

Further reading

• Rodenas E, Klerkx EP, Ayuso C, Audhya A, Askjaer P . Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly. . Developmental Biology . 327 . 2 . 399–409 . 2009 . 19146848 . 10.1016/j.ydbio.2008.12.024 . 10261/17735 . 13344975 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, etal . The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. . Mol. Cell . 22 . 1 . 93–103 . 2006 . 16600873 . 10.1016/j.molcel.2006.02.015 . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW . Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex . Mol. Biol. Cell . 16 . 5 . 2382–94 . 2005 . 15703211 . 10.1091/mbc.E04-10-0857 . 1087243 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Cronshaw JM, Krutchinsky AN, Zhang W, etal . Proteomic analysis of the mammalian nuclear pore complex . J. Cell Biol. . 158 . 5 . 915–27 . 2002 . 12196509 . 10.1083/jcb.200206106 . 2173148 .

Notes and References

1. Web site: Entrez Gene: NUP35 nucleoporin 35kDa.