Nucleobindin 2 Explained

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.^{[1] [2]}

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.^{[3] [4]}

Interactions

NUCB2 has been shown to interact with NDN.^[5]

Further reading

• DeAngelis MM, Doucet JP, Drury S, Sherry ST, Robichaux MB, Den Z, Pelias MZ, Ditta GM, Keats BJ, Deininger PL, Batzer MA . 6 . Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1407 . 1 . 84–91 . July 1998 . 9639681 . 10.1016/s0925-4439(98)00025-8 . free .
• Kroll KA, Otte S, Hirschfeld G, Barnikol-Watanabe S, Götz H, Sternbach H, Kratzin HD, Barnikol HU, Hilschmann N . 6 . Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites . Biochemical and Biophysical Research Communications . 260 . 1 . 1–8 . June 1999 . 10381334 . 10.1006/bbrc.1999.0867 .
• Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K . The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm . The Journal of Biological Chemistry . 275 . 41 . 31674–31681 . October 2000 . 10915798 . 10.1074/jbc.M005103200 . free.
• Nesselhut J, Jurgan U, Onken E, Götz H, Barnikol HU, Hirschfeld G, Barnikol-Watanabe S, Hilschmann N . 6 . Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region . FEBS Letters . 509 . 3 . 469–475 . December 2001 . 11749975 . 10.1016/S0014-5793(01)03187-8 . 31134537 .
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC . Serological identification and expression analysis of gastric cancer-associated genes . British Journal of Cancer . 86 . 11 . 1824–1830 . June 2002 . 12087473 . 2375403 . 10.1038/sj.bjc.6600321 .
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 . The Journal of Biological Chemistry . 279 . 45 . 47242–47253 . November 2004 . 15308636 . 10.1074/jbc.M406644200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Islam A, Adamik B, Hawari FI, Ma G, Rouhani FN, Zhang J, Levine SJ . Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex . The Journal of Biological Chemistry . 281 . 10 . 6860–6873 . March 2006 . 16407280 . 10.1074/jbc.M509397200 . free .

Notes and References

1. Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N . 6 . Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein . Biological Chemistry Hoppe-Seyler . 375 . 8 . 497–512 . August 1994 . 7811391 . 10.1515/bchm3.1994.375.8.497 .
2. Web site: Entrez Gene: NUCB2 nucleobindin 2.
3. Yañez-Guerra LA, Thiel D, Jékely G . Premetazoan Origin of Neuropeptide Signaling . Molecular Biology and Evolution . 39 . 4 . msac051 . April 2022 . 35277960 . 9004410 . 10.1093/molbev/msac051 . O'Connell M .
4. Web site: Callier V . 2022-06-03 . Brain-Signal Proteins Evolved Before Animals Did . 2022-06-03 . Quanta Magazine . en.
5. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K . The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm . The Journal of Biological Chemistry . 275 . 41 . 31674–31681 . October 2000 . 10915798 . 10.1074/jbc.M005103200 . free.