Nuclear mitotic apparatus protein 1 explained

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.^{[1] [2]}

Interactions

Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1,^[3] Band 4.1,^[4] GPSM2^[5] and EPB41L1.^[6]

Further reading

• Sun QY, Schatten H . Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein . Front. Biosci. . 11 . 1137–46 . 2006 . 16146802 . 10.2741/1868 . free .
• Yang CH, Lambie EJ, Snyder M . NuMA: an unusually long coiled-coil related protein in the mammalian nucleus . J. Cell Biol. . 116 . 6 . 1303–1317 . 1992 . 1541630 . 10.1083/jcb.116.6.1303 . 2289379 .
• Compton DA, Szilak I, Cleveland DW . Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis . J. Cell Biol. . 116 . 6 . 1395–1408 . 1992 . 1541636 . 10.1083/jcb.116.6.1395 . 2289377 .
• Lydersen BK, Pettijohn DE . Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell . Cell . 22 . 2 Pt 2 . 489–499 . 1981 . 7004645 . 10.1016/0092-8674(80)90359-1 . 27884304 .
• Maekawa T, Kuriyama R . Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic MAP located at the spindle pole and characterized as a homologous protein to NuMA . J. Cell Sci. . 105 . 2. 589–600 . 1993 . 10.1242/jcs.105.2.589 . 8408288 .
• Tang TK, Tang CJ, Chen YL, Wu CW . Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1 . J. Cell Sci. . 104 . 2. 249–60 . 1993 . 10.1242/jcs.104.2.249 . 8505359 .
• Wells RA, Catzavelos C, Kamel-Reid S . Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia . Nat. Genet. . 17 . 1 . 109–113 . 1997 . 9288109 . 10.1038/ng0997-109 . 21975861 .
• Andrade F . Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis . Immunity . 8 . 4 . 451–460 . 1998 . 9586635 . 10.1016/S1074-7613(00)80550-6 . Roy S . Nicholson D . Thornberry . Nancy . Rosen . Antony . Casciola-Rosen . Livia . free .
• Novick D . Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response . Immunity . 10 . 1 . 127–136 . 1999 . 10023777 . 10.1016/S1074-7613(00)80013-8 . Kim SH . Fantuzzi G . Reznikov . Leonid L . Dinarello . Charles A . Rubinstein . Menachem . free .
• Mattagajasingh SN . A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein . J. Cell Biol. . 145 . 1 . 29–43 . 1999 . 10189366 . 10.1083/jcb.145.1.29 . 2148212 . Huang SC . Hartenstein JS . Snyder . M . Marchesi . VT . Benz . EJ .
• Clark IB, Meyer DI . Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase . J. Cell Sci. . 112 . 20. 3507–18 . 2000 . 10.1242/jcs.112.20.3507 . 10504299 .
• Ye K . Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor . J. Neurosci. . 19 . 24 . 10747–56 . 2000 . 10594058 . 10.1523/JNEUROSCI.19-24-10747.1999. Compton DA . Lai MM . Walensky . LD . Snyder . SH . free . 6784956.
• Taimen P, Viljamaa M, Kallajoki M . Preferential expression of NuMA in the nuclei of proliferating cells . Exp. Cell Res. . 256 . 1 . 140–149 . 2000 . 10739661 . 10.1006/excr.2000.4799 .
• Harborth J, Weber K, Osborn M . GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA . J. Biol. Chem. . 275 . 41 . 31979–31985 . 2000 . 10913114 . 10.1074/jbc.M000994200 . free . 11858/00-001M-0000-0012-F868-B . free .
• Gregson HC . A potential role for human cohesin in mitotic spindle aster assembly . J. Biol. Chem. . 276 . 50 . 47575–47582 . 2002 . 11590136 . 10.1074/jbc.M103364200 . Schmiesing JA . Kim JS . Kobayashi . T . Zhou . S . Yokomori . K . free.
• Du Q, Stukenberg PT, Macara IG . A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization . Nat. Cell Biol. . 3 . 12 . 1069–1075 . 2002 . 11781568 . 10.1038/ncb1201-1069 . 7955950 .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . Lyon CE . Fox AH . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Haren L, Merdes A . Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules . J. Cell Sci. . 115 . Pt 9 . 1815–24 . 2002 . 10.1242/jcs.115.9.1815 . 11956313 .
• Sbodio JI, Chi NW . Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner . J. Biol. Chem. . 277 . 35 . 31887–31892 . 2002 . 12080061 . 10.1074/jbc.M203916200 . free .

Notes and References

1. Sparks CA, Bangs PL, McNeil GP, Lawrence JB, Fey EG . Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13 . Genomics . 17 . 1 . 222–224 . Oct 1993 . 8406455 . 10.1006/geno.1993.1307 .
2. Web site: Entrez Gene: NUMA1 nuclear mitotic apparatus protein 1.
3. Bhattacharya . Nandini . Wang Zeping . Davitt Christine . McKenzie Ian F C . Xing Pei-Xiang . Magnuson Nancy S . Jul 2002 . Pim-1 associates with protein complexes necessary for mitosis . Chromosoma . 111 . 2 . 80–95 . Germany. 0009-5915. 12111331 . 10.1007/s00412-002-0192-6 . 26016943 .
4. Mattagajasingh . S N . Huang S C . Hartenstein J S . Snyder M . Marchesi V T . Benz E J . Apr 1999 . A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein . J. Cell Biol. . 145 . 1 . 29–43 . UNITED STATES. 0021-9525. 10189366 . 10.1083/jcb.145.1.29 . 2148212 .
5. Du . Q . Stukenberg P T . Macara I G . Dec 2001 . A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization . Nat. Cell Biol. . 3 . 12 . 1069–1075 . England. 1465-7392. 11781568 . 10.1038/ncb1201-1069 . 7955950 .
6. Ye . K . Compton D A . Lai M M . Walensky L D . Snyder S H . Dec 1999 . Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor . J. Neurosci. . 19 . 24 . 10747–56 . UNITED STATES. 10594058 . 6784956 . 10.1523/JNEUROSCI.19-24-10747.1999 .