Nuclear factor I explained

Nuclear factor I (NF-I) is a family of closely related transcription factors. They constitutively bind as dimers to specific sequences of DNA with high affinity.^[1] Family members contain an unusual DNA binding domain that binds to the recognition sequence 5'-TTGGCXXXXXGCCAA-3'.^[2]

Subtypes include:

• NFIA
• NFIB
• NFIC
• NFIX

Notes and References

1. Blomquist P, Belikov S, Wrange O . Increased nuclear factor 1 binding to its nucleosomal site mediated by sequence-dependent DNA structure . Nucleic Acids Res. . 27 . 2 . 517–25 . January 1999 . 9862974 . 148209 . 10.1093/nar/27.2.517.
2. Book: Walter F. Boron . Medical Physiology: A Cellular And Molecular Approaoch . Elsevier/Saunders . 2003 . 125–126 . 1-4160-2328-3 .