Nuclear calcium explained

The concentration of calcium in the cell nucleus can increase in response to signals from the environment. Nuclear calcium is an evolutionary conserved potent regulator of gene expression that allows cells to undergo long-lasting adaptive responses. The 'Nuclear Calcium Hypothesis’ by Hilmar Bading describes nuclear calcium in neurons as an important signaling end-point in synapse-to-nucleus communication that activates gene expression programs needed for persistent adaptations.[1] In the nervous system, nuclear calcium is required for long-term memory formation, acquired neuroprotection, and the development of chronic inflammatory pain.[2] [3] [4] [5] In the heart, nuclear calcium is important for the development of cardiac hypertrophy.[6] [7] In the immune system, nuclear calcium is required for human T cell activation.[8] Plants use nuclear calcium to control symbiosis signaling.[9]

Notes and References

  1. Bading. H.. 2000-09-01. Transcription-dependent neuronal plasticity: the nuclear calcium hypothesis. European Journal of Biochemistry. 267. 17. 5280–5283. 10.1046/j.1432-1327.2000.01565.x. 0014-2956. 10951185. free.
  2. Weislogel. Jan-Marek. Bengtson. C. Peter. Müller. Michaela K.. Hörtzsch. Jan N.. Bujard. Martina. Schuster. Christoph M.. Bading. Hilmar. 2013-05-07. Requirement for nuclear calcium signaling in Drosophila long-term memory. Science Signaling. 6. 274. ra33. 10.1126/scisignal.2003598. 1937-9145. 23652205. 7112258.
  3. Zhang. Sheng-Jia. Zou. Ming. Lu. Li. Lau. David. Ditzel. Désirée A. W.. Delucinge-Vivier. Celine. Aso. Yoshinori. Descombes. Patrick. Bading. Hilmar. 2009-08-01. Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity. PLOS Genetics. 5. 8. e1000604. 10.1371/journal.pgen.1000604. 1553-7404. 2718706. 19680447 . free .
  4. Simonetti. Manuela. Hagenston. Anna M.. Vardeh. Daniel. Freitag. H. Eckehard. Mauceri. Daniela. Lu. Jianning. Satagopam. Venkata P.. Schneider. Reinhard. Costigan. Michael. 2013-01-09. Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron. 77. 1. 43–57. 10.1016/j.neuron.2012.10.037. 1097-4199. 3593630. 23312515.
  5. Bading. Hilmar. Nuclear calcium signalling in the regulation of brain function. Nature Reviews Neuroscience. 14. 9. 593–608. 10.1038/nrn3531. 23942469. 2013. 14896252.
  6. Higazi. Daniel R.. Fearnley. Claire J.. Drawnel. Faye M.. Talasila. Amarnath. Corps. Elaine M.. Ritter. Oliver. McDonald. Fraser. Mikoshiba. Katsuhiko. Bootman. Martin D.. 2009-02-27. Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes. Molecular Cell. 33. 4. 472–482. 10.1016/j.molcel.2009.02.005. 1097-4164. 19250908. free.
  7. Guatimosim. Silvia. Amaya. Maria Jimena. Guerra. Mateus T.. Aguiar. Carla J.. Goes. Alfredo M.. Gómez-Viquez. Norma Leticia. Rodrigues. Michele A.. Gomes. Dawidson A.. Martins-Cruz. Juliana. 2008-08-01. Nuclear Ca2+ regulates cardiomyocyte function. Cell Calcium. 44. 2. 230–242. 10.1016/j.ceca.2007.11.016. 0143-4160. 18201761.
  8. Monaco. Sara. Jahraus. Beate. Samstag. Yvonne. Bading. Hilmar. 2016-10-24. Nuclear calcium is required for human T cell activation. J Cell Biol. en. 215. 2. 231–243. 10.1083/jcb.201602001. 0021-9525. 5084645. 27810914.
  9. Oldroyd. Giles E. D.. Downie. J. Allan. 2006-08-01. Nuclear calcium changes at the core of symbiosis signalling. Current Opinion in Plant Biology. 9. 4. 351–357. 10.1016/j.pbi.2006.05.003. 1369-5266. 16713329.

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