NsiR4 small RNA explained

NsiR4 sRNA
Rfam:RF002677
Tax Domain:Bacteria

NsiR4 (nitrogen stress-induced RNA 4), former name SyR12, is a cyanobacterial non-coding RNA which plays role in the regulation of Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation. NsiR4 interacts with the 5′UTR of the mRNA of the GS inactivating factor IF7 (gifA mRNA) and reduces its expression. NsiR4 expression is under positive control of the nitrogen control transcription factor (NtcA). NsR4 is a first example of an sRNA controlling the assimilation of a micronutrient.[1]

Notes and References

  1. Klähn S, Schaal C, Georg J, Baumgartner D, Knippen G, Hagemann M, Muro-Pastor AM, Hess WR . The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7 . Proceedings of the National Academy of Sciences of the United States of America . 112 . 45 . E6243–6252 . November 2015 . 26494284 . 4653137 . 10.1073/pnas.1508412112 . 2015PNAS..112E6243K . free .