NPR3 explained

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.^[1]

Function

The family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.^[1]

See also

• Atrial natriuretic peptide receptor

References

Further reading

• Fox AA, Collard CD, Shernan SK, etal . Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. . Anesthesiology . 110 . 4 . 738–47 . 2009 . 19326473 . 10.1097/ALN.0b013e31819c7496. 2735337 .
• Moffatt P, Thomas G, Sellin K, etal . Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. . J. Biol. Chem. . 282 . 50 . 36454–62 . 2007 . 17951249 . 10.1074/jbc.M708596200 . 7185411 . free .
• Pitzalis MV, Sarzani R, Dessì-Fulgheri P. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. . J. Hypertens. . 21 . 8 . 1491–6 . 2003 . 12872042 . 10.1097/00004872-200308000-00012 . 11566/50999 . 40988095 . etal. free .
• Fan D, Bryan PM, Antos LK, etal . Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize. . Mol. Pharmacol. . 67 . 1 . 174–83 . 2005 . 15459247 . 10.1124/mol.104.002436 . 53520 .
• He XL, Chow DC, Martick MM, Garcia KC . Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. . Science . 293 . 5535 . 1657–62 . 2001 . 11533490 . 10.1126/science.1062246 . 2001Sci...293.1657H . 6030635 .
• Soranzo N, Rivadeneira F, Chinappen-Horsley U, etal . Visscher . Peter M. . Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. . PLOS Genet. . 5 . 4 . e1000445 . 2009 . 19343178 . 10.1371/journal.pgen.1000445 . 2661236 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• He XL, Dukkipati A, Garcia KC . Structural determinants of natriuretic peptide receptor specificity and degeneracy. . J. Mol. Biol. . 361 . 4 . 698–714 . 2006 . 16870210 . 10.1016/j.jmb.2006.06.060 .
• Rubattu S, Stanzione R, Di Angelantonio E, etal . Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. . Stroke . 35 . 4 . 814–8 . 2004 . 15017020 . 10.1161/01.STR.0000119381.52589.AB . free .
• Iemitsu M, Maeda S, Otsuki T, etal . Arterial stiffness, physical activity, and atrial natriuretic Peptide gene polymorphism in older subjects. . Hypertens. Res. . 31 . 4 . 767–74 . 2008 . 18633189 . 10.1291/hypres.31.767 . free .
• Dickey DM, Yoder AR, Potter LR . A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation. . J. Biol. Chem. . 284 . 29 . 19196–202 . 2009 . 19458086 . 10.1074/jbc.M109.010777 . 2740543 . free .
• Gratacòs M, Costas J, de Cid R. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 150B . 6 . 808–16 . 2009 . 19086053 . 10.1002/ajmg.b.30902 . 44524739 . etal.
• Aoi N, Soma M, Nakayama T, etal . Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. . Hypertens. Res. . 27 . 10 . 711–6 . 2004 . 15785005 . 10.1291/hypres.27.711 . free .
• Anand-Srivastava MB . Natriuretic peptide receptor-C signaling and regulation. . Peptides . 26 . 6 . 1044–59 . 2005 . 15911072 . 10.1016/j.peptides.2004.09.023 . 6734231 .
• Estrada K, Krawczak M, Schreiber S, etal . A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. . Hum. Mol. Genet. . 18 . 18 . 3516–24 . 2009 . 19570815 . 10.1093/hmg/ddp296 . 2729669 .
• Burgess MD, Moore KD, Carter GM, etal . C-type natriuretic peptide receptor expression in pancreatic alpha cells. . Histochem. Cell Biol. . 132 . 1 . 95–103 . 2009 . 19352691 . 10.1007/s00418-009-0591-3 . 9116972 .
• Vassalle C, Andreassi MG, Prontera C, etal . Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure. . Clin. Chem. . 53 . 11 . 1886–90 . 2007 . 17890443 . 10.1373/clinchem.2007.088302 . free .
• Lee JK, Kim HT, Cho SM, etal . Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. . J. Hum. Genet. . 48 . 5 . 213–6 . 2003 . 12768436 . 10.1007/s10038-003-0011-9 . free .
• van den Akker F . Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors. . J. Mol. Biol. . 311 . 5 . 923–37 . 2001 . 11556325 . 10.1006/jmbi.2001.4922 .
• He XL, Dukkipati A, Wang X, Garcia KC . A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C. . Peptides . 26 . 6 . 1035–43 . 2005 . 15911071 . 10.1016/j.peptides.2004.08.035 . 28281513 .

Notes and References

1. Web site: Entrez Gene: NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C).