| Official Name: | Novotyryshkino |
| Native Name: | Новотырышкино |
| Settlement Type: | Selo |
| Pushpin Map: | Russia Altai Krai#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Name1: | Altai Krai |
| Subdivision Name3: | Smolensky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +7:00 |
| Coordinates: | 52.0833°N 138°W[1] |
Novotyryshkino (Russian: Новотырышкино) is a rural locality (a selo) and the administrative center of Novotyryshkinsky Selsoviet, Smolensky District, Altai Krai, Russia. The population was 1,880 as of 2013.[2] There are 22 streets in the locality.
Novotyryshkino is located 38 km southwest of Smolenskoye (the district's administrative centre) by road. Sychyovka is the nearest rural locality.[3]