| Novomoskovsk uezd | |
| Native Name: | Новомосковскій уѣздъ |
| Native Name Lang: | ru |
| Settlement Type: | Uezd |
| Mapsize: | 225px |
| Subdivision Type: | Country |
| Subdivision Name: | Russian Empire |
| Subdivision Type1: | Governorate |
| Subdivision Name1: | Yekaterinoslav |
| Established Title: | Established |
| Established Date: | 1784 |
| Extinct Title: | Abolished |
| Extinct Date: | 1923 |
| Seat Type: | Capital |
| Seat: | Novomoskovsk |
| Area Total Km2: | 6532.24 |
| Population As Of: | 1897 |
| Population Total: | 260,368 |
| Population Density Km2: | auto |
The Novomoskovsk uezd (; Ukrainian: Новомосковський повіт|Novomoskovs'kyi povit) was one of the subdivisions of the Yekaterinoslav Governorate of the Russian Empire. It was situated in the northwestern part of the governorate. Its administrative centre was Novomoskovsk.
At the time of the Russian Empire Census of 1897, Novomoskovsky Uyezd had a population of 260,368. Of these, 93.2% spoke Ukrainian, 3.7% Russian, 1.4% Yiddish, 1.3% German, 0.1% Polish, 0.1% Romani and 0.1% Belarusian as their native language.[1]