| Official Name: | Novo Santo Antônio |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Coordinates: | -5.2883°N -41.9333°W |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | Northeast |
| Subdivision Type2: | State |
| Subdivision Name2: | Piauí |
| Subdivision Type3: | Mesoregion |
| Subdivision Type4: | Microregion |
| Subdivision Type5: | Metrop. region |
| Leader Title: | Mayor |
| Area Total Km2: | 481.71 |
| Population Total: | 3,003 |
| Population As Of: | 2020 [1] |
| Population Density Km2: | auto |
| Timezone1: | BRT |
| Utc Offset1: | -3 |
| Postal Code Type: | Postal code |
| Area Code Type: | Area code |
Novo Santo Antônio (Portuguese for "New Saint Anthony") is a Brazilian municipality of the state of Piauí. The population is 3,003 (2020 est.) in an area of 481.71 km2.[2]
The municipality contains the Araguaia State Park, created in 2001.