| Province: | NS |
| Type: | Route |
| Route: | 366 |
| Length Km: | 47 |
| Length Round: | 0 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in East Amherst |
| Junction: | in Tidnish Bridge |
| Terminus B: | in Port Howe |
| Previous Type: | Route |
| Previous Route: | 362 |
| Next Type: | Route |
| Next Route: | 368 |
Route 366 is a collector road in the Canadian province of Nova Scotia.
It is located in Cumberland County and connects East Amherst at Trunk 6 with Port Howe on Trunk 6.
At Tidnish Bridge the road connects to Route 970 at inter-provincial boundary with New Brunswick.
The entirety of the Collector Highway 366 was once designated as the Trunk Highway 66.