| Province: | NS |
| Type: | Route |
| Route: | 245 |
| Length Km: | 63 |
| Length Round: | 0 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in Sutherlands River |
| Junction: | in Malignant Cove |
| Terminus B: | in Antigonish |
| Counties: | Pictou, Antigonish |
| Previous Type: | Route |
| Previous Route: | 242 |
| Next Type: | Route |
| Next Route: | 246 |
Route 245 is a collector road in the Canadian province of Nova Scotia. Route 245 is part of the Sunrise Trail.
The route spans Pictou and Antigonish counties and connects Sutherlands River at Exit 27 on Highway 104 with Antigonish at Trunk 4.
The entirety of Collector Highway 245 was once designated as Trunk Highway 45.