| Notre Dame High School | |
| Motto: | Veritas vincit omnia |
| Motto Translation: | Truth conquers all |
| Address: | 2701 Vermont Avenue |
| City: | Chattanooga |
| State: | Tennessee |
| Zipcode: | 37404 |
| Country: | United States |
| Denomination: | Roman Catholic |
| Oversight: | Diocese of Knoxville |
| Superintendent: | Dr. Sedonnna Prater |
| President: | Deacon Hicks Armor |
| Principal: | Jamie Goodhard |
| Chaplain: | Fr. Christopher Manning |
| Average Class Size: | 18 |
| Ratio: | 1:10 |
| Type: | Private, Coeducational |
| Tuition: | $13,499 (Catholic); $17,729 (non-Catholic) |
| Enrolment: | 397 (2022-2023) |
| Grades: | 9–12 |
| Campus Size: | 20acres |
| Fight Song: | Victory March |
| Accreditation: | Southern Association of Colleges and Schools |
| Mascot: | Leprechaun |
| Patron: | Our Lady of Lourdes |
| Team Name: | Fighting Irish |
| Nickname: | Shamrock Nation |
| Yearbook: | Irish Echoes |
Notre Dame High School is a private, Roman Catholic college-preparatory day school in Chattanooga, Tennessee. Founded in 1876, it is Chattanooga's oldest private school. The current campus, dedicated in 1966, is located in the Glenwood neighborhood adjacent to Memorial Hospital. Notre Dame was the first racially integrated high school in Chattanooga.