Notholaenic acid explained

Notholaenic acid is a dihydrostilbenoid found in the farina of some ferns of the genus Notholaena.[1] It has been shown to have anti-HSV-1 (Herpes simplex virus 1) activity at high concentrations in vitro.[2] It was artificially synthesized, starting from 3-benzyloxy-5-methoxybenzyl alcohol, in 1985.[3]

Notes and References

  1. Wollenweber . Eckhard . Favre-Bonvin . Jean . Novel dihydrostilbene from fronds of Notholaena dealbata and Notholaena limitanea . Phytochemistry . 1979 . 18 . 7 . 1243–1244 . 10.1016/0031-9422(79)80153-3.
  2. Rinehart. Kenneth L. . Tom G. Holt . Nancy L. Fregeau . Paul A. Keifer . George Robert Wilson . Thomas J. Perun Jr . Ryuichi Sakai . Anthony G. Thompson . Justin G. Stroh . Lois S. Shield . David S. Seigler . Li H. Li . David G. Martin . Cornelis J. P. Grimmelikhuijzen . Gerd Gäde . Bioactive Compounds from Aquatic and Terrestrial Sources. Journal of Natural Products. July–August 1990. 53. 4 . 771–792. 10.1021/np50070a001. 2095373 .
  3. Total Synthesis of Notholaenic Acid . Farouk S. . El-Feraly . Steve F. . Cheatham . James D. . McChesney . Journal of Natural Products . 1985 . 48 . 2 . 293–298 . 10.1021/np50038a015.

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