Norzoanthamine Explained

Norzoanthamine is an alkaloid found in soft corals of the genus Zoanthus

Norzoanthamine has been shown to suppress the loss of bone weight and strength in mice.[1] Some derivatives of norzoanthamine also suppress development of some kind of leukemia cell lines and human platelet aggregation.[2]

A laboratory synthesis of this compound was developed in 2004.[3]

References

  1. García-García . Patricia . Reyes . Ricardo . Évora . Carmen . Delgado . Araceli . Fernández . José J. . Daranas . Antonio Hernández . March 2022 . Osteoprotective effect of the marine alkaloid norzoanthamine on an osteoporosis model in ovariectomized rat . Biomedicine & Pharmacotherapy . en . 147 . 112631 . 10.1016/j.biopha.2022.112631. 10261/258849 . free .
  2. Villar . Rosa M . Gil-Longo . José . Daranas . Antonio H . Souto . Marı́a L . Fernández . José J . Peixinho . Solange . Barral . Miguel A . Santafé . Gilmar . Rodrı́guez . Jaime . Jiménez . Carlos . May 2003 . Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets . Bioorganic & Medicinal Chemistry . en . 11 . 10 . 2301–2306 . 10.1016/S0968-0896(03)00107-X.
  3. 10.1126/science.1098851 . Total Synthesis of Norzoanthamine . 2004 . Miyashita . M. . Science . 305 . 5683 . 495–9 . 15205476 . Sasaki . M . Hattori . I . Sakai . M . Tanino . K. 2004Sci...305..495M . 27964116 . free .

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