Norwogonin Explained

Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap).^[1] It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).^[2]

See also

• Tropomyosin receptor kinase B § Agonists

Notes and References

1. Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, Morgan MA, Nichols WS, Van Benschoten MM, Hardy WD, Liu GY . 6 . Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii . PLOS ONE . 8 . 4 . e61594 . 2013 . 23630600 . 3632535 . 10.1371/journal.pone.0061594 . 2013PLoSO...861594M . Khan . Asad U . free .
2. Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K . 6 . A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect . Journal of Medicinal Chemistry . 53 . 23 . 8274–86 . December 2010 . 21073191 . 3150605 . 10.1021/jm101206p .