Ethinylestradiol/norethisterone explained

Type:combo
Component1:Ethinylestradiol
Class1:Estrogen
Component2:Norethisterone
Class2:Progestogen
Tradename:Alyacen, Aranelle, Balziva, others
Dailymedid:Norethindrone and ethinyl estradiol
Routes Of Administration:By mouth
Atc Prefix:G03
Atc Suffix:AA05
Legal Us:Rx-only
Cas Number:37270-71-6
Pubchem:62925
Chemspiderid:None
Synonyms:EE/NET

Ethinylestradiol/norethisterone (EE/NET), or ethinylestradiol/norethindrone, is a combination birth control pill which contains ethinylestradiol (EE), an estrogen and norethisterone (NET), a progestin.[1] It is used for birth control, symptoms of menstruation, endometriosis, and menopausal symptoms.[1] Other uses include acne.[1] It is taken by mouth.[1] Some preparations of EE/NET additionally contain an iron supplement in the form of ferrous fumarate.[2]

Side effects can include nausea, headache, blood clots, breast pain, depression, and liver problems. Use is not recommended during pregnancy, the initial three weeks after childbirth, and in those at high risk of blood clots.[3] It, however, may be started immediately after a miscarriage or abortion.[4] Smoking while using combined birth control pills is not recommended.[5] It works by stopping ovulation, making the uterus not suitable for implantation, and making the mucus at the opening to the cervix thick.[4]

This combination pill was approved for medical use in the United States in 1964.[6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[8] It is marketed under a large number of brand names.[9] In 2021, it was the 52nd most commonly prescribed medication in the United States, with more than 12million prescriptions.[10] [11]

See also

Notes and References

  1. Web site: Ethinyl estradiol and norethindrone (HRT) medical facts from Drugs.com. www.drugs.com. 23 December 2016. live. https://web.archive.org/web/20161224163928/https://www.drugs.com/mtm/ethinyl-estradiol-and-norethindrone-hrt.html. 24 December 2016.
  2. Book: Hamilton, Richard J. . Tarascon Pocket Pharmacopoeia 2020 Deluxe Lab-Coat Edition. 30 April 2020. Jones & Bartlett Learning. 978-1-284-40304-6. 347–.
  3. Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . ((World Health Organization)) . Stuart MC, Kouimtzi M, Hill SR . 10665/44053 . World Health Organization . World Health Organization . free . 365 .
  4. Web site: Brevinor Tablets - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. 23 December 2016. live. https://web.archive.org/web/20161224095216/https://www.medicines.org.uk/emc/medicine/1899. 24 December 2016.
  5. Web site: Estrogen-Progestin Combinations. The American Society of Health-System Pharmacists. 8 December 2016. live. https://web.archive.org/web/20161223132621/https://www.drugs.com/monograph/estrogen-progestin-combinations.html. 23 December 2016.
  6. Book: Haussman. Melissa. Reproductive Rights and the State: Getting the Birth Control, RU-486, Morning-after Pills and the Gardasil Vaccine to the U.S. Market. 2013. ABC-CLIO. 9780313398223. 72. en. live. https://web.archive.org/web/20161224100703/https://books.google.ca/books?id=QpIUmKPDao0C&pg=PA72. 24 December 2016.
  7. Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO .
  8. Book: Hamilton. Richart. Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. 2015. Jones & Bartlett Learning. 9781284057560. 353.
  9. Web site: Alyacen 1/35 (birth control) medical facts from Drugs.com. www.drugs.com. live. https://web.archive.org/web/20161224095847/https://www.drugs.com/mtm/alyacen-1-35-birth-control.html. 24 December 2016.
  10. Web site: The Top 300 of 2021 . ClinCalc . 14 January 2024 . 15 January 2024 . https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx . live .
  11. Web site: Ethinyl Estradiol; Norethindrone - Drug Usage Statistics . ClinCalc . 14 January 2024.

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