The Northwest Hoosier Conference was an IHSAA-sanctioned conference based in northwestern Indiana. The conference was started by five schools in 1968, and faced numerous membership changes during its span. The far-flung conference folded in 1998, when four of its members joined other leagues, and the other three schools were unable to find suitable replacements.
| School | Location | Mascot | Colors | County | Year joined | Previous Conference | Year left | Conference Joined | |
|---|---|---|---|---|---|---|---|---|---|
| Knox | Knox | Redskins | 75 Starke | 1968 | Independents | 1982 | Northern State | ||
| North Judson- San Pierre | North Judson | Bluejays | 75 Starke | 1968 | Independents | 1998 | Independents (HNAC 2015) | ||
| Rensselaer Central | Rensselaer | Bombers | 37 Jasper | 1968 | Independents | 1998 | Hoosier | ||
| Twin Lakes | Monticello | Indians | 91 White | 1968 | Independents | 1974 | Hoosier | ||
| Winamac | Winamac | Warriors | 66 Pulaski | 1968 | Hoosier | 1981 | Midwest | ||
| Kankakee Valley | Wheatfield | Kougars | 37 Jasper | 1972 | Midwest | 1998 | Independents (LAC 2003) | ||
| Lake Station Edison | Lake Station | Eagles | 45 Lake | 1974 | Independents | 1998 | Lake | ||
| North Newton | Morocco | Spartans | 56 Newton | 1975 | Midwest | 1998 | Independents (GSSC 2007) | ||
| West Central | Francesville | Trojans | 66 Pulaski | 1975 | Midwest | 1980 | Midwest | ||
| River Forest | Lake Station | Ingots | 45 Lake | 1985 | Independents | 1998 | Northland | ||
| Lowell | Lowell | Red Devils | 45 Lake | 1993 | Lake Suburban | 1998 | Lake |