| Official Name: | North Santee, South Carolina |
| Settlement Type: | Unincorporated Community |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Georgetown |
| Established Title2: | Unincorporated |
| Timezone: | Eastern |
| Area Code: | 843 |
North Santee is an unincorporated community in Georgetown County, South Carolina, United States. It is located south of Georgetown on U.S. Route 17 on the Santee River. Thomas Lynch, Jr. was born here at the Hopsewee house.