| State: | NC |
| Type: | NC |
| Route: | 381 |
| Map: | NC 381 map.svg |
| Length Mi: | 10.6 |
| Length Round: | 1 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | at the South Carolina state line in Gibson |
| Junction: | near Hamlet |
| Terminus B: | near Hamlet |
| Counties: | Scotland, Richmond |
| Established: | 1940 |
| Previous Type: | NC |
| Previous Route: | 345 |
| Next Type: | NC |
| Next Route: | 400 |
North Carolina Highway 381 (NC 381) is a primary state highway in the U.S. state of North Carolina. The highway connects the cities of Hamlet and Gibson.
NC 381 is a two-lane rural highway that traverses 10.6miles from the South Carolina state line in Gibson to U.S. Route 74 Business near Hamlet. The highway is flanked with farms and has little traffic.
Established in 1940 as a renumbering of NC 78 when the route was extended to the South Carolina state line, connecting with SC 381; remained unchanged since inception.[1]