Norpsilocin Explained
| Drug Name: | Norpsilocin |
| Cas Number: | 28363-70-4 |
| Pubchem: | 14107683 |
| Chemspiderid: | 27283888 |
| Chembl: | 4648350 |
| Iupac Name: | 3-[2-(methylamino)ethyl]-1H-indol-4-ol |
| C: | 11 |
| H: | 14 |
| N: | 2 |
| O: | 1 |
| Smiles: | CNCCC1=CNC2=C1C(=CC=C2)O |
| Stdinchi: | 1S/C11H14N2O/c1-12-6-5-8-7-13-9-3-2-4-10(14)11(8)9/h2-4,7,12-14H,5-6H2,1H3 |
| Stdinchikey: | MTJOWJUQGYWRHT-UHFFFAOYSA-N |
Norpsilocin (4-HO-NMT) is a tryptamine alkaloid recently discovered in 2017 in the psychedelic mushroom Psilocybe cubensis.[1] [2] It is hypothesized to be a dephosphorylated metabolite of baeocystin. Norpsilocin was found to be a near full agonist of the 5-HT2A receptor. It is also more potent than psilocin.[3] [4]
See also
Notes and References
- Lenz C, Wick J, Hoffmeister D . Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product . . 80 . 10 . 2835–2838 . October 2017 . 28929753 . 10.1021/acs.jnatprod.7b00407 .
- Web site: Two New Crystalline Forms of Norpsilocin.
- Web site: Study Finds Norpsilocin is More Potent Than Psilocin at 5-HT2A.
- Sherwood AM, Halberstadt AL, Klein AK, McCorvy JD, Kaylo KW, Kargbo RB, Meisenheimer P . Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin . . 83 . 2 . 461–467 . February 2020 . 32077284 . 10.1021/acs.jnatprod.9b01061 .
