Norcycloartenol Explained

29- or 31-Norcycloartenol, also called 4α,14α-dimethyl-9β,19-cyclo-5α-cholest-24-en-3β-ol, is a Metabolic intermediate of plant sterol biosynthesis.^{[1] [2] [3] [4]} In the pathway, it is transformed from demethylation of cycloartenol, then 9,19-cyclopropyl-ring opening reaction occurs to 29-Norlanosterol.^[5]

Notes and References

1. Zheng . S . Ma . Z . Ye . J . Wang . G . Wang . R . Zhou . H . Zeng . S . Jiang . H . Determination of three triterpene alcohols in rat plasma after oral administration of pollen of Brassica campestris based on the utilization of fetal bovine serum as surrogate matrix. . Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences . 1 January 2014 . 944 . 11–7 . 10.1016/j.jchromb.2013.10.044 . 24291607.
2. Bellamine . A . Mangla . AT . Dennis . AL . Nes . WD . Waterman . MR . Structural requirements for substrate recognition of Mycobacterium tuberculosis 14 alpha-demethylase: implications for sterol biosynthesis. . Journal of Lipid Research . January 2001 . 42 . 1 . 128–36 . 10.1016/S0022-2275(20)32344-0 . 11160374. free .
3. Bayer . M . Proksch . P . Felsner . I . Brenden . H . Kohne . Z . Walli . R . Duong . TN . Götz . C . Krutmann . J . Grether-Beck . S . Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure. . Experimental Dermatology . November 2011 . 20 . 11 . 955–8 . 10.1111/j.1600-0625.2011.01350.x . 21824200. 28583844 . free .
4. Hartmann . MA . Perret . AM . Carde . JP . Cassagne . C . Moreau . P . Inhibition of the sterol pathway in leek seedlings impairs phosphatidylserine and glucosylceramide synthesis but triggers an accumulation of triacylglycerols. . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 8 August 2002 . 1583 . 3 . 285–96 . 10.1016/s1388-1981(02)00249-4 . 12176396.
5. Web site: Rosa chinensis plant sterol biosynthesis II . pmn.plantcyc.org.