Norcodeine Explained

Norcodeine is an opiate analogue that is the N-demethylated derivative of codeine. It has relatively little opioid activity in its own right,[1] but is formed as a metabolite of codeine following ingestion.[2]

Norcodeine is a Schedule I Narcotic controlled substance in the US with the ACSCN of 9309 and zero annual manufacturing quota. The salts in use are the acetate (free base conversion ratio 0.826), hydroiodide (0.662), hydrochloride (0.759), nitrate (0.819), platinichloride (0.582), and sulphate (0.744).[3]

See also

Notes and References

  1. Fraser HF, Isbell H, Vanhorn GD . Human pharmacology and addiction liability of norcodeine . The Journal of Pharmacology and Experimental Therapeutics . 129 . 172–7 . June 1960 . 13824628 .
  2. Posey BL, Kimble SN . High-performance liquid chromatographic study of codeine, norcodeine, and morphine as indicators of codeine ingestion . Journal of Analytical Toxicology . 8 . 2 . 68–74 . 1984 . 6716978 . 10.1093/jat/8.2.68 .
  3. Web site: Quotas - 2014 . DEA Diversion Control Division .

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