Nonabine Explained

Nonabine (BRL-4664) is an experimental drug which is a synthetic THC analog.[1] It was studied in the 1980s for the prevention of nausea and vomiting associated with cancer chemotherapy but was never marketed.[1] It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2] [3]

Notes and References

  1. Staquet M, Bron D, Rozencweig M, Kenis Y . Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting . Journal of Clinical Pharmacology . 21 . S1 . 60S–63S . 1981 . 7197692 . 10.1002/j.1552-4604.1981.tb02575.x . 30609591 .
  2. Archer CB, Amlot PL, Trounce JR . Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine . British Medical Journal . 286 . 6362 . 350–1 . January 1983 . 6402096 . 1546960 . 10.1136/bmj.286.6362.350-a .
  3. McClelland GR, Sutton JA . Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects . Psychopharmacology . 85 . 3 . 306–8 . 1985 . 2860687 . 10.1007/BF00428192 . 19560039 .

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