Non-Langerhans cell histiocytosis explained

Non-Langerhans cell histiocytosis
Synonyms:	Rare histiocytoses
Field:	Hematology

Non-Langerhans cell histiocytosis, also known as rare histiocytoses, comprise all histiocyte, macrophage, and dendritic cell proliferative disorders that are not categorized as hemophagocytic lymphohistiocytosis (HLH) or Langerhans cell histiocytosis (LCH).^[1]

The spectrum of non-langerhans cell histiocytoses include:

• Benign cephalic histiocytosis
• Generalized eruptive histiocytoma
• Indeterminate cell histiocytosis
• Juvenile xanthogranuloma
• Progressive nodular histiocytoma
• Necrobiotic xanthogranuloma
• (Giant Cell) Reticulohistiocytoma
• Multicentric reticulohistiocytosis
• Rosai–Dorfman disease
• Xanthoma disseminatum
• Kikuchi disease
• Erdheim–Chester disease.^[2]

Further reading

• Weitzman . Sheila . Jaffe . Ronald . Uncommon histiocytic disorders: The non-Langerhans cell histiocytoses . Pediatric Blood & Cancer . 45 . 3 . 2005 . 1545-5009 . 10.1002/pbc.20246 . 256–264 . 15547923 . 25621667 . none.
• Book: Froehlich . Stephan J. . Lackerbauer . Carlo A. . Rudolph . Guenter . Rémi . Jan . Noachtar . Soheyl . Heppt . Werner J. . Cryer . Annette . Zenner . Hans-Peter . Niller . Hans Helmut . Schwarzmann . Fritz . Wolf . Hans . Frieling . Thomas . Leung . Alexander K. C. . Wallgren-Pettersson . Carina . Goebel . Hans H. . Jouret . François . Devuyst . Olivier . Attanasio . Massimo . Hildebrandt . Friedhelm . Jha . Vivekanand . Chugh . Kirpal S. . Marinaki . Anthony M. . Simmonds . H. Anne . Zhou . Xiaoyan . Frohlich . Edward D. . Tesar . Vladimir . Jalanko . Hannu . Oji . Vinzenz . Traupe . Heiko . Danek . Adrian . Angelini . Corrado . Kaufmann . Dieter . Kaufmann . Dieter . Weller . Michael . Kornhuber . Johannes . Vincent . Angela . Newsom-Davis . John . Mole . Sara . Williams . Ruth . Baets . Jonathan . Hanemann . C. Oliver . Jonghe . Peter . Holt . Ian . Klopstock . Thomas . Zeviani . Massimo . Ley . Klaus . Smith . Emily . Shiohara . Masaaki . Leung . Alexander K. C. . Robson . William Lane M. . Brokalaki . Eirini I. . Grabbe . Stephan . Loquai . Carmen . Nohr . Donatus . Nohr . Donatus . Gallinat . Jürgen . Schuchman . Edward H. . Desnick . Robert J. . Zeitz . Christina . Mizutani . Shuki . Orange . Jordan S. . Weiss . Jeffrey P. . Blaivas . Jerry G. . Robson . William Lane M. . Leung . Alexander K. C. . Ma . Lucia K. . Ma . Patrick T. S. . Leung . Alexander K. C. . Schwarz . Peter E. H. . Li . Jiang . LeRoith . Derek . Kure . Shigeo . Tada . Keiya . Utikal . Jochen . Gratchev . Alexei . Goerdt . Sergij . Senzolo . Marco . Piovesana . Elena . Okolicsanyi . Lajos . Burroughs . Andrew K. . Sistermans . Erik A. . Engel . Jutta . Fischer . M. Dominik . Berger . Wolfgang . Tozzi . Maria Grazia . Micheli . Vanna . Leung . Alexander K. C. . Robson . William Lane M. . Encyclopedia of Molecular Mechanisms of Disease . Non-Langerhans' Cell Histiocytoses . Springer Berlin Heidelberg . Berlin, Heidelberg . 2009 . 978-3-540-67136-7 . 10.1007/978-3-540-29676-8_1296 . none.

Notes and References

1. Classen . C. . Minkov . M. . Lehrnbecher . T. . The Non-Langerhans Cell Histiocytoses (Rare Histiocytoses) – Clinical Aspects and Therapeutic Approaches . Klinische Pädiatrie . Georg Thieme Verlag KG . 228 . 6/07 . November 15, 2016 . 0300-8630 . 10.1055/s-0042-109713 . 294–306 . 27846659 . 22814976 . de.
2. Rao RN, Chang CC, Uysal N, Presberg K, Shidham VB, Tomashefski JF . Fulminant multisystem non-langerhans cell histiocytic proliferation with hemophagocytosis: a variant form of Erdheim-Chester disease . Arch. Pathol. Lab. Med. . 129 . 2 . e39–43 . February 2005 . 15679446 . 10.5858/2005-129-e39-FMNCHP.