Naked cuticle 2 explained

Naked cuticle 2 (NKD2) is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway.[1] [2] Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only Nkd2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.[3]

Sources

  1. Wharton . KA Jr . Zimmermann . G . Rousset . R . Scott . MP . Jun 2001 . Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling . Dev. Biol. . 234 . 1. 93–106 . 10.1006/dbio.2001.0238 . 11356022 . 18903944 . free .
  2. Katoh . M . Nov 2001 . Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2 . Int J Oncol . 19 . 5. 963–9 . 11604995 . 10.3892/ijo.19.5.963.
  3. Li . C . Franklin . JL . Graves-Deal . R . Jerome . WG . Cao . Z . Coffey . RJ . Apr 2004 . Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells . Proc Natl Acad Sci U S A . 101 . 15. 5571–6 . 10.1073/pnas.0401294101 . 15064403 . 397424. 2004PNAS..101.5571L . free .

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