| Official Name: | Nixville, South Carolina |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | Nixville |
| Pushpin Label Position: | left |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Hampton |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 105 |
| Coordinates: | 32.7431°N -81.1519°W |
| Area Code: | 803 & 839 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1249880 |
Nixville is an unincorporated community in Hampton County, South Carolina, United States. The community is on South Carolina Highway 3 east of Estill.
On April 13, 2020, a tornado measuring EF4 on the Enhanced Fujita Scale traveled across Hampton County, striking Nixville along its path. The tornado, which was part of the 2020 Easter tornado outbreak, killed five people in the Nixville and Estill vicinities and caused a significant amount of property damage.[1]